This present study aimed to examine the effects of long-term resistance exercise REG and aerobic exercise AEG on the adiponectin, insulin resistance, lipid profile and body composition in adolescent boys with obesity. Sixteen obese adolescent boys age: The serum lipid profile, adiponectin, glucose, insulin resistance HOMA-IR levels and body composition of the participants were evaluated at the beginning and end of the study. A Wilcoxon matched-pairs signed-rank test and Mann-Whitney U test were used for analyses, and the criterion for statistical significance was set at p HOMA-IR, insulin, glucose and serum lipid levels decreased in both groups p These results indicated that both types of exercises had positive effects on insulin resistance, per cent body fat, weight and fat-free body mass. Long-term 6 months aerobic and REG had different positive effects on adiponectin and the lipid profile. The prevalence of being overweight and obesity in children, adolescents and adults have risen substantially worldwide 1. The European Union Action Plan on Childhood Obesity emphasises physical activity as well as a regulated diet in children to halt this increase in the number of overweight and obese adolescents by 2. Adipokines secreted from adipose tissue may play a key role in the pathogenesis of obesity, insulin resistance and atherosclerosis by increasing subclinical inflammation 3. Adiponectin is one of the main adipokines secreted from adipose tissue. Adiponectin facilitates the clearing of glucose, triglycerides and free fatty acids from plasma; it decreases gluconeogenesis and increases insulin sensitivity 4. Individuals with obesity have lower adiponectin but higher leptin levels than individuals without obesity 5. Leptin is a hormone released by adipose tissue that aids in the regulation of body weight and energy homeostasis. Increased fat mass causes an elevation in leptin levels, which signal satiety and a mild increase in the basal energy expenditure. However, exercise can also cause changes in leptin concentration without an accompanying change in body composition. Different forms of exercise training could favourably modify weight-related complications, cardiovascular risk factors and the inflammation 6. Recently, resistance exercise has been recommended for children with obesity. While aerobic exercise is primarily an aerobic energy-producing process, resistance exercise is a type of exercise that increases primarily the force generation capacity of muscles 7. No consensus exists about the probable role of exercise in children on reductions in body fat and its effect on adipokines e. Only a few studies Escort Infrared Door Key investigated the effects of resistance exercise on adipokines, lipids and insulin resistance in adolescents 9, Information about health-related factors and early intervention effects among adolescents with obesity are important Escort Infrared Door Key in establishing targeted strategies and promoting lifestyle changes for preventing diseases. A better understanding of the metabolic responses to different types of exercise may help tailor interventions to maximise the likelihood of achieving health benefits among adolescents with obesity. Within this context, the main purpose of this study was to compare the effects of structured six-month resistance versus aerobic-exercise programmes on the serum lipid profile, adiponectin and insulin resistance. For the recruitment of voluntary participants, we contacted state high schools near the selected fitness centre in the Sisli district Escort Infrared Door Key Istanbul. From this group, adolescents with obesity were selected according to Cole et al. Twenty-three students and their parents decided to participate in the 6-month study and provided informed consent. Seven of the participants dropped out of the study because of various reasons non-compliance with the exercise schedule, Ramadan fasting period discontinuationand the study was completed with 16 participants. The study was performed, followed by the ethical guidelines of the Declaration of Helsinki. Before data collection, all participants provided written informed consent. Since all participants were younger than 18 years old, parents also gave written permission for participation. The participants did not have any sports experience before the study. An experienced physician reviewed their complete medical history, performed a physical examination and assessed pubertal development according to the Tanner criteria. The Tanner stage was determined on a paper chart by the bariatric paediatrician during the physical examination of the participants The Tanner scale defines stages based on the development of pubic hair and testicular volume in males. All participants were in Tanner stage IV-V. The investigation was performed as a parallel-group design and lasted for six months. However, a structured diet programme was not implemented throughout the study. The participants were asked not to consume any antioxidant supplements throughout the study. This study was conducted using two groups in a pre-post design interventional study without a control group at the Marmara University Athletic Health Research Center, İstanbul, Turkey. The duration of the study was six months. All participants visited the research unit three times, and they were familiarised with all experimental tests before the baseline performance.
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Sensepoint XRL – Ribble Enviro Ltd. Research Articles. Key Words: Biomedicine, Nanoparticles, Carbon nanotubes, Drug Delivery. Ocular Drug Delivery Routes: Diseases Overview and Advanced. Anticancer Property of Orthosiphon stamineus Benth. This issue is published electronically on December CONTENTS. Volume 45, Issue 3 – FABAD Journal of Pharmaceutical SciencesOn the other hand, at 48 hours, all doses of caffeic acid phenethyl ester statistically remarkably decreased cell migration. In conclusion, the hyaluronic acid serum formulation has been evaluated as a product that can be used safely for moisturizing the skin. With some degrees of burns it prevents suppuration and creates a protective barrier. This work can be extended to in vivo by using disease-specific therapeutic genetic materials. Traditional knowledge about using local plants was collected through field surveys. The values of Q2 LOO 0.
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Anticancer Property of Orthosiphon stamineus Benth. The aircraft platform will be equipped with two turboprop engines and critical payloads such as EO/IR camera, AESA radar, Beyond Line of Sight (satellite). She alleged that she had been raped by two men on 31 July and 1 August , when she was 14 years and 10 months old. Research Articles. The ensuing investigation came to the. This issue is published electronically on December CONTENTS. Ocular Drug Delivery Routes: Diseases Overview and Advanced. Key Words: Biomedicine, Nanoparticles, Carbon nanotubes, Drug Delivery.Ulagay İlaç Sanayii Türk A. However, acquiring uninterrupted knowledge of psoriasis pathophysiology allows us to identify the novel therapeutic targets that could be explored to overcome personalized psoriasis treatment challenges. This result may support the use of breadfruit leaf extract as herbal drug with a hepatoprotective effect. In this study, it is found that community pharmacists make an effort to increase the drug compliance of patients. Technological developments lead to changes in the field of health as well as in many areas. Long-term 6 months aerobic and REG had different positive effects on adiponectin and the lipid profile. This article provides a comprehensive review of the benefits and applications of AI in various stages of drug discovery. In the light of the latest advances, AI has become the focus of the pharmaceutical industry. Carvacrol and epigallocatechin gallate are naturally derived substances with anticancer, antioxidant, and apoptotic properties. Polyvinyl alcohol PVA is a biocompatible, easily degradable, and flexible polymer with mucoadhesive properties used in industrial, commercial, and medical applications. The relative bioavailability of the new formulation has been shown, and both products were introduced as safe. Similarly, drugs encapsulated within nanoparticles can be protected from premature degradation and released in a controlled manner at the target site improving their drug solubility, and enhance cellular uptake, leading to better therapeutic effect in treatment strategies. Wound dressings made of biodegradable polymers do not require a second procedure for removal. With this point of view breastfeeding mothers are commonly using herbal products to raise their milk production galactagogue or treat post-natal diseases. Acetylcholineinduced endothelium-dependent relaxations were reduced in the adult rats compared with young. The optimized solid dispersion FL10 prepared via lyophilization had an average particle size of The data obtained in the research were analyzed with the SPSS ver. Moreover, the molecular interactions help in the understanding of the underlying mechanism of action of this marker compound against gout. The optimized cubosomal dispersion was further assessed for particle size, in vitro IFS release, hemolysis, cytotoxicity, cellular uptake, and physical stability. As a result, egr-miR is a promising potential target for the diagnosis of CE. In predicting the 3-year mortality, SII demonstrated superior diagnostic performance compared to other inflammatory indices Area under the curve: 0. These synthetic derivatives exhibit a broad spectrum of therapeutic activities, and understanding the essential features responsible for the observed pharmacological effects has been pivotal in structureactivity relationship studies. The experimental design was evaluated for model fit with the assistance of variance analysis. However, its toxicity effect still remained unknown. Key Words: antibacterial, aminothiazole, benzothiazole, benzofurane, naphtofurane. The elastic liposomal suspension was then incorporated into optimised gelling agent carbopol to have sufficient contact time of the drug in the eye. Mercury exposure is suggested to cause neurological disorders. In this study, 5 new Schiff base compounds containing triazole-imidazole rings were synthesized. Exendin-4, which is widely used in incretin-based therapies, binds to GLP-1 receptors with high affinity, causing glucose-dependent insulin secretion in the body, delaying gastric emptying, suppressing glucagon release and appetite. The radiolabeling was performed under room conditions, and labeling efficiency and stability were evaluated by paper chromatography and HPLC. Monitoring of the drug levels can be very important for efficient drug treatment. IC50 values were determined in neuroblastoma and healthy astrocyte cells using the MTT assay.
